General Information

  • ID:  hor001995
  • Uniprot ID:  NA
  • Protein name:  GnRH
  • Gene name:  NA
  • Organism:  NA
  • Family:  GnRH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  CHWSYGLRPG
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be conjugated to tetanus toxoid (TT) or diphtheria toxoid (DT) and formulated with Quil A saponin or a sustained release injectible PLGA (poly(lactide-co-glycolide)/triacetin) that caused significant reduction in testosterone and follicle stimulating hormone levels, resulting in marked suppression of spermatogenesis
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001995_AF2.pdbhor001995_ESM.pdb

Physical Information

Mass: 133604 Formula: C53H74N16O13S
Absent amino acids: ADEFIKMNQTV Common amino acids: G
pI: 8.53 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: -68 Boman Index: -1271
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 6875 Extinction Coefficient cystines: 6990
Absorbance 280nm: 776.67

Literature

  • PubMed ID:  16483697
  • Title:  Evaluation of Two GnRH-I Based Vaccine Formulations on the Testes Function of Entire Suffolk Cross Ram Lambs